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Foyes Principles of Medicinal Chemistry.

Wilson and Giswolds Organic medicinal and Pharmaceutical Chemistry.

Reference Books (Latest Editions to be adopted) UNIT V- Drugs acting on Central Nervous System 07

Miscellaneous: Primidone, Valproic acid, Gabapentin, Felbamate 2.

Urea and monoacylureas: Phenacemide, Carbamazepine*.

Succinimides: Phensuximide, Methsuximide, Ethosuximide*.

Oxazolidine diones: Trimethadione, Paramethadione.

Hydantoins: Phenytoin*, Mephenytoin, Ethotoin.

Barbiturates: Phenobarbitone, Methabarbital.

Anticonvulsants: SAR of Anticonvulsants, mechanism of anticonvulsant action.

Beta amino ketones: Molindone hydrochloride.

Fluro buterophenones: Haloperidol, Droperidol, Risperidone.

Ring Analogues of Phenothiazeines: Chlorprothixene, Thiothixene, Loxapine succinate, Clozapine.

Phenothiazeines: SAR of Phenothiazeines – Promazine hydrochloride, Chlorpromazine hydrochloride*, Triflupromazine, Thioridazine hydrochloride, Piperacetazine hydrochloride, Prochlorperazine maleate, Trifluoperazine hydrochloride.

Aldehyde & their derivatives: Triclofos sodium, Paraldehyde. Alcohol & their carbamate derivatives: Meprobomate, Ethchlorvynol.

Miscelleneous: Amides and imides:Glutethmide.

Barbiturtes: SAR of barbiturates, Barbital*, Phenobarbital, Mephobarbital, Amobarbital, Butabarbital, Pentobarbital, Secobarbital.

Benzodiazepines: SAR of Benzodiazepines, Chlordiazepoxide, Diazepam*, Oxazepam, Chlorazepate, Lorazepam, Alprazolam, Zolpidem.

UNIT IV – Drugs acting on Central Nervous System 08

Synthetic cholinergic blocking agents: Tropicamide, Cyclopentolate hydrochloride, Clidinium bromide, Dicyclomine hydrochloride*, Glycopyrrolate, Methantheline bromide, Propantheline bromide, Benztropine mesylate, Orphenadrine citrate, Biperidine hydrochloride, Procyclidine hydrochloride*, Tridihexethyl chloride, Isopropamide iodide, Ethopropazine hydrochloride.

Solanaceous alkaloids and analogues: Atropine sulphate, Hyoscyamine sulphate, Scopolamine hydrobromide, Homatropine hydrobromide, Ipratropium bromide*.

Cholinergic Blocking agents: SAR of cholinolytic agents.

Cholinesterase reactivator: Pralidoxime chloride.

Indirect acting/ Cholinesterase inhibitors (Reversible & Irreversible): Physostigmine, Neostigmine*, Pyridostigmine, Edrophonium chloride, Tacrine hydrochloride, Ambenonium chloride, Isofluorphate, Echothiophate iodide, Parathione, Malathion.

Direct acting agents: Acetylcholine, Carbachol*, Bethanechol, Methacholine, Pilocarpine.

Parasympathomimetic agents: SAR of Parasympathomimetic agents.

Cholinergic receptors (Muscarinic & Nicotinic) and their distribution 2

Biosynthesis and catabolism of acetylcholine.

UNIT III – Cholinergic neurotranimitters 10 UNIT II – Drugs acting on Autonomic Nervous System 10

Factors affecting drug metabolism including stereo chemical aspects 5.

Drug metabolism principles- Phase I and Phase II.

Physicochemical properties in relation to biological action Ionization, Solubility, Partition Coefficient, Hydrogen bonding, Protein binding, Chelation, Bioisosterism, Optical and Geometrical isomerism 4.History and development of medicinal chemistry 1.UNIT I – Introduction to Medicinal Chemistry 10 write the chemical synthesis of some drugs.know the Structural Activity Relationship (SAR) of different class of drugs.understand the drug metabolic pathways, adverse effect and therapeutic value of drugs.understand the chemistry of drugs with respect to their pharmacological activity.Upon completion of the course the student shall be able to:

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BP402T: Medicinal Chemistry I – Theory Syllabus for B.Pharm 4th Sem 2019 Pattern Mumbai Universityįor the complete Syllabus, results, class timetable, and many other features kindly download the iStudy App The detailed syllabus scheme for medicinal chemistry i – theory is as follows. For all other Mumbai University B.Pharm 4th Sem Syllabus 2019 Pattern, do visit B.Pharm 4th Sem 2019 Pattern Scheme.

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